Eye Diseases

Prof. Dr. Ahmet Murat Sarıcı

Medical Fields

    1.    Ophthalmology
   •    General care for eye disorders.
    2.    Ocular Oncology
   •    Specialization in eye cancers, including retinoblastoma, melanoma, and other intraocular tumors.
    3.    Pediatric Ophthalmology
   •    Management of eye disorders in children, particularly in cases like congenital retinoblastoma.
    4.    Orbital Surgery
   •    Focused on conditions affecting the eye socket and surrounding structures.
    5.    Reconstructive Surgery
   •    Rebuilding the ocular structure post-tumor removal.
    6.    Radiation Oncology (Ocular Application)
   •    For radiation-based treatment of eye cancers (e.g., brachytherapy, external beam radiotherapy).
    7.    Pathology (Ocular Pathology)
   •    Biopsy and analysis of ocular tumors.
    8.    Medical Genetics
   •    Genetic counseling and testing for hereditary ocular cancers like retinoblastoma.
    9.    Plastic and Reconstructive Ophthalmology
   •    Specialized reconstructive procedures for the eyelids, orbit, and ocular surface.
    10.    Neuro-Ophthalmology
   •    Management of visual issues linked to neurological conditions, which may overlap with cancer spreading to optic nerves.

 

Surgical Procedures

    1.    Enucleation
    •    Surgical removal of the entire eyeball, often for retinoblastoma or other advanced ocular cancers.
    2.    Evisceration
    •    Removal of the inner contents of the eye while preserving the sclera and extraocular muscles.
    3.    Exenteration
    •    Removal of the eyeball and surrounding tissues (e.g., muscles, eyelids) for extensive tumors.
    4.    Brachytherapy (Plaque Radiotherapy)
    •    Placement of radioactive plaques to treat ocular tumors such as uveal melanoma or retinoblastoma.
    5.    Retinoblastoma Tumor Surgery
    •    Microsurgical removal of intraocular tumors in early stages (rarely performed, as most cases are managed with laser or chemotherapy).
    6.    Vitrectomy
    •    Removal of the vitreous gel, often used in cases of tumor-related retinal detachment or diagnostic biopsy.
    7.    Cryotherapy
    •    Freezing treatment to destroy cancerous cells or shrink tumors.
    8.    Laser Photocoagulation
    •    Using a laser to destroy blood supply to small tumors.
    9.    Scleral Buckling Surgery
    •    Used for retinal detachment caused by tumor growth.
    10.    Chemotherapy Delivery Techniques
    •    Intravitreal Chemotherapy: Injection of chemotherapy drugs directly into the eye.
    •    Subtenon Chemotherapy: Injection around the eyeball for localized delivery.
    •    Intra-arterial Chemotherapy: Delivering drugs directly to the ophthalmic artery.
    11.    Orbital Tumor Excision
    •    Removal of tumors in the orbit (eye socket).
    12.    Lid Sparing Surgery
    •    Tumor removal surgeries while preserving eyelids.
    13.    Corneal Transplantation (if needed)
    •    Replacement of a damaged cornea post-surgical intervention.
    14.    Optic Nerve Resection
    •    Performed when the tumor extends to the optic nerve.
    15.    Prosthetic Eye Implantation
    •    After enucleation or exenteration, fitting an artificial eye for aesthetic purposes.
    16.    Endoscopic Orbital Surgery
    •    Minimally invasive surgeries for orbital tumors using endoscopic techniques.

 

Advanced/Interdisciplinary Procedures

    1.    Onco-Reconstructive Surgery
    •    Combining oncological tumor removal with reconstructive techniques.
    2.    Orbital Decompression Surgery
    •    To relieve pressure caused by tumors or post-surgical swelling.
    3.    Multidisciplinary Surgical Interventions
    •    Collaborations with neurosurgeons, oncologists, and plastic surgeons for cases with brain or facial involvement.

Education:

    •    Hacettepe University, Faculty of Medicine
    •    Istanbul University, Cerrahpaşa Faculty of Medicine



Academic Appointments:


    •    Wills Eye Hospital: Specialized training in ocular oncology under Prof. Dr. Jerry Shields and Prof. Dr. Carol Shields.
    •    University of Michigan, Kellogg Eye Center: Research on thyroid-related ophthalmopathy and orbital decompression.
    •    Istanbul University, Cerrahpaşa Faculty of Medicine Hospital: Clinical practice and academic contributions.

 

Professional Memberships:

    •    European Board of Ophthalmology (EBO)
    •    International Council of Ophthalmology (ICO)
    •    American Academy of Ophthalmology (AAO)
    •    European VitreoRetinal Society (EVRS)
    •    Turkish Ophthalmological Association (TOD)
    •    International Ocular Oncology Society (ISOO)

1- Fluorescein angiographic findings after intra-arterial chemotherapy for retinoblastoma.

Bianciotto C, Shields CL, Iturralde JC, Sarici A, Jabbour P, Shields JA.Ophthalmology. 2012 Apr;119(4):843-9. doi: 10.1016/j.ophtha.2011.09.040. Epub 2011 Dec 2.PMID: 22137042

 

 

2- Episcleral Iodine-125 radioactive plaque brachytherapy as a salvage treatment for retinoblastoma in the era of intraarterial chemotherapy.

Sarıcı AM, Celkan TT, Oto BB, Şahin A, Uzel Ö, Uçar D.Turk J Pediatr. 2022;64(2):285-292. doi: 10.24953/turkjped.2021.4

 

 

3- Comparison of iodine-125 plaque brachytherapy and gamma knife stereotactic radiosurgery treatment outcomes for uveal melanoma patients.

Guleser UY, Sarici AM, Ucar D, Gonen B, Sengul Samanci N, Özgüroğlu M.Graefes Arch Clin Exp Ophthalmol. 2022 Apr;260(4):1337-1343. doi: 10.1007/s00417-021-05472-x. Epub 2021 Nov 4.PMID: 34735632

 

 

4- Superselective intra-arterial chemotherapy treatment for retinoblastoma: clinical experience from a tertiary referral centre.

Batu Oto B, Sarıcı AM, Kızılkılıç O.Can J Ophthalmol. 2020 Oct;55(5):406-412. doi: 10.1016/j.jcjo.2020.04.009. Epub 2020 Jun 8.

 

 

5- Intraoperative relaxed muscle positioning technique results in a tertiary Center for Thyroid Orbitopathy Related Strabismus.

Sarici AM, Mergen B, Oguz V, Dogan C.BMC Ophthalmol. 2018 Nov 23;18(1):305. doi: 10.1186/s12886-018-0974-0.

 

6- Investigation of retinal nerve fiber layer thickness and ganglion cell layer-inner plexiform layer thickness in patients with optic pathway gliomas.

Hepokur M, Sarici AM.Graefes Arch Clin Exp Ophthalmol. 2018 Sep;256(9):1757-1765. doi: 10.1007/s00417-018-4007-8. Epub 2018 May 12.PMID: 29754292

 

7- Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy.

Dikkaya F, Sarıcı AM, Erbek F, Celkan T, Mangan MS, Aydın Ö, Demirkesen C, Pazarlı H.Int Ophthalmol. 2018 Feb;38(1):151-156. doi: 10.1007/s10792-016-0436-8. Epub 2017 Jan 5.

 

 

8- An alternative technique of the superselective catheterization of the ophthalmic artery for intra-arterial chemotherapy of the retinoblastoma: retrograde approach through the posterior communicating artery to the ophthalmic artery.

Saglam M, Sarici A, Anagnostakou V, Yildiz B, Kocer N, Islak C, Kizilkilic O.Neuroradiology. 2014 Sep;56(9):751-4. doi: 10.1007/s00234-014-1388-1. Epub 2014 Jun 10.PMID: 24913287

 

 

9- Combined excision, cryotherapy, and intraoperative mitomycin C (EXCRIM) for localized intraepithelial and squamous cell carcinoma of the conjunctiva.

Sarici AM, Arvas S, Pazarli H.Graefes Arch Clin Exp Ophthalmol. 2013 Sep;251(9):2201-4. doi: 10.1007/s00417-013-2437-x. Epub 2013 Aug 16.PMID: 23949688

 

 

10- Blue toe syndrome as a complication of intra-arterial chemotherapy for retinoblastoma.

Sarici A, Kizilkilic O, Celkan T, Gode S.JAMA Ophthalmol. 2013 Jun;131(6):801-2. doi: 10.1001/jamaophthalmol.2013.1458.PMID: 23764710 No abstract available.

 

 

 

11- The association of carotid cavernous fistula with Graves' ophthalmopathy.

Celik O, Buyuktas D, Islak C, Sarici AM, Gundogdu AS.Indian J Ophthalmol. 2013 Jul;61(7):349-51. doi: 10.4103/0301-4738.109533.PMID: 23571267

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