IVF Department

Prof. Dr. Lale Bakir

Infertility
IVF
Reproductive Genetics and Biopsy
Regenerative Medicine
Stem Cell and Cellular Therapies
Gynecological Endocrinology
Menopause
Endometriosis
Pelvic Pain
Minimally Invasive Surgery

Education:

Graduated from Faculty of Medicine and Year
Istanbul University Faculty of Medicine, 2004


Place and Year of Specialization Training
Zeynep Kamil Gynecology and Pediatrics Training and Research Hospital, Gynecology and Obstetrics Clinic, 2010



Academic Appointments:

Medipol Mega IVF Unit, 2021-2022
Kolan Hospital, IVF Unit, 2021
Medicana International Hospital, Gynecology and Obstetrics Clinic, IVF Unit, 2020-2021
Haseki Training and Research Hospital, Gynecology and Obstetrics Clinic, Chief Assistant, 2013-2020
University of Illinois at Chicago, Department of Obstetrics and Gynecology, Stem Cell Research Laboratory, 2019
Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, Gynecology and Obstetrics Clinic, 2010-2013
Istinye University, Institute of Health Sciences, Stem Cell and Tissue Engineering Program, 2018
Istanbul University, Istanbul Medical Faculty IVF Training Program, 2018
Medipol University Faculty of Medicine, Department of Obstetrics and Gynecology, Reproductive Medicine – IVF Unit, 2021

International Publications

* Bakir B, Bakan S, Tunaci M, Bakir VL, Iyibozkurt AC, Berkman S, Bengisu E, Salmaslioglu A. Diffusion-weighted imaging of solid or predominantly solid gynaecological adnexial masses: is it useful in the differential diagnosis? Br J Radiol. 2011 Jul;84(1003):600-11. doi: 10.1259/bjr/90706205. Epub 2010 Nov 16

* Akbayir O, Corbacioglu A, Goksedef BP, Numanoglu C, Akca A, Guraslan H, Bakir LV, Cetin A. The novel criteria for predicting pelvic lymph node metastasis in endometrioid adenocarcinoma of endometrium. Gynecol Oncol. 2012 May;125(2):400-3. doi: 10.1016/j.ygyno.2012.01.051. Epub 2012 Feb 3.

* Corbacioglu A, Bakir VL, Akbayir O, Cilesiz Goksedef BP, Akca A.The role of pregnancy awareness on female sexual function in early gestation. J Sex Med. 2012 Jul;9(7):1897-903. doi: 10.1111/j.1743-6109.2012.02740.x. Epub 2012 Apr 23.

* Kara N, Yildirim Y, Tekirdag AI, Yildirim GY, Bakir VL, Gulac B, Yilmaz G, Fendal A. Effect of body posture on intraocular pressure and ocular perfusion pressure in nonglaucomatous pregnant women. Curr Eye Res. 2013 Jan;38(1):80-5. doi: 10.3109/02713683.2012.713157. Epub 2012 Aug 7.

* Akbayır O, Corbacıoglu Esmer A, Numanoglu C, Cılesız Goksedef BP, Akca A, Bakır LV, Kuru O. Influence of body mass index on clinicopathologic features, surgical morbidity and outcome in patients with endometrial cancer. Arch Gynecol Obstet. 2012 Nov;286(5):1269-76.

* Sariibrahim B, Cogendez E, Kayatas S, Asoglu MR, Koleli I, Bakir VL. Does Kruger's strict criteria have prognostic value in predicting ICSI clinical results? Clin Exp Obstet Gynecol. 2013;40(2):257-60.

* Corbacioglu Esmer A, Akca A, Akbayir O, Goksedef BP, Bakir VL.Female sexual function and associated factors during pregnancy. J Obstet 

Gynaecol Res. 2013 Jun;39(6):1165-72. doi: 10.1111/jog.12048. Epub 2013 May 30.

* Goksedef BP1, Akbayir O, Numanoglu C, Corbacioglu A, Guraslan H, Bakir VL, Kaya O, Yanik G, Cetin A. Evaluation of endocervical canal in women with minimal cervical cytological abnormalities. J Low Genit Tract Dis. 2013 Jul;17(3):261-6. doi: 10.1097/LGT.0b013e31826b68c7.

* Sakar MN, Atay AE, Demir S, Bakir VL, Demir B, Balsak D, Akay E, Ulusoy AI, Verit FF. Association of endothelial nitric oxide synthase gene G894T polymorphism and serum nitric oxide levels in patients with preeclampsia and gestational hypertension. J Matern Fetal Neonatal Med. 2014 Oct 20:1-6.

* Koleli IK, Ozdogan E, Sariibrahim B, Bakir VL, Karateke A. Prognostic factors. Eur. J. Gynaec. Oncol. - ISSN: 0392-2936XXXV, n. 4, 2014
doi: 10.12892/ejgo24552014

* Sakinci M, Kuru O, Olgan S, Gunduz S, Bakir VL, Kaya O, Bakirci IT. Dilatation of the cervix at non-labour caesarean section: Does it improve the patients' perception of pain post-operatively? J Obstet Gynaecol. 2015;35(7):681-4. doi: 10.3109/01443615.2015.1004533.

* Sakar MN, Gultekin H, Demir B, Bakir VL, Balsak D, Vuruskan E, Acar H, Yucel O, Yayla M. Ramadan fasting and pregnancy: implications for fetal development in summer season. J Perinat Med. 2015 May;43(3):319-23. doi: 10.1515/jpm-2013-02

* Dundar O, Pektas MK, Bodur S, Bakır VL, Cetin A. Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width. J Obstet Gynaecol Res. 2014 Nov 5. doi: 10.1111/jog.12600.

* Bakir VL, Bakir B, Sanli S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E.Role of diffusion-weighted MRI in the differential diagnosis of endometrioid and non-endometrioid cancer of the uterus.Acta Radiol. 2016 Jan 1:284185116669873. doi: 10.1177/0284185116669873.

* Bakir VL, Ozgur Dundar, Serkan Bodur, et al. Mean platelet volume as an inexpensive bio-marker of endometriosis Int J Clin Exp Med 2016;9(4):XXX-XXX www.ijcem.com /ISSN:1940-5901/IJCEM0011915

* Kanat-Pektas M, Bodur S, Dundar O, Bakır VL. Systematic review: What is the best first-line approach for cesarean section ectopic pregnancy? Taiwan J Obstet Gynecol. 2016 Apr;55(2):263-9. doi: 10.1016/j.tjog.2015.03.009. 

* Bakir B, Sanli S, Bakir VL, Ayas S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E. Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening. Clin Imaging. 2017 Jan - Feb;41:86-94. doi:10.1016/j.clinimag.2016.10.016. 

* Koleli IK, Parlakpinar H, Ozhan O, Tanbek K, Sahin N, Yilmaz E, Sariibrahim B, Bakir VL. Molsidomine (MOL) reduces postoperative pelvic adhesion: A rat uterine horn model. Annals of Medical Research , 2019;26(2):260-4

* Park HS, Chugh RM, Elsharoud A, Ulin M, Esfandyari S, Aboalsoud A, Bakir L, Al-Hendy A. Safety of intraovarian injection of human mesenchymal stem cells in a premature ovarian ınsufficiency mouse model. Cell Transplant. 2021 Jan-Dec;30:963689720988502.

* Chugh RM, Park HS, El Andaloussi A, Elsharoud A, Esfandyari S, Ulin M, Bakir L, Aboalsoud A, Ali M, Ashour D, Igboeli P, Ismail N, McAllister J, Al-Hendy. Mesencyhmal stem cell therapy ameliorates metabolic dysfunction and restores fertility in a PCOS mouse model through interleukin-10. Stem Cell Res Ther. 2021 Jul 7;12(1):388.

 

National Publications

* Polat I, Akagündüz N, Yildirim G, Ulker V, Bakir VL, Ekiz A, Tekirdag A The Effects of Type of Delivery on Pelvic Floor and Bladder Neck JOPP Dergi 4(2):47-60, 2012 doi:10.5222/JOPP.2012.047

* Polat I, Hasbajrami A, Yildirim G, Ülker V, Bakir VL Effects of gonadotropin releasing hormone antagonist addition in ovulation induction protocol in infertile patients JOPP Derg 4(1):1-9, 2012 doi:10.5222/JOPP.2012.001

* Cokyaman N, Bakir VL, Tekirdağ A, Yildirim G, Polat I. Does maternal ß-thalassemia minor increase the risk of fetal anomaly and incidence of complications? The importance of ß-thalassemia in pregnacies with Microcytic Anemia JOPP Derg 4(2):61-68, 2012 doi:10.5222/JOPP.2012.061

* Ekmez M, Dane C, Akgüneş A, Ekmez F, Göksedef P, Aydın DS, Bakir VL, İnce S, Yücel E The Evaluation of Laparoscopic Hysterectomies in Our Clinic Med Bull Haseki 2017;55:311-4 

* Bakir VL Does insulin resistance and impaired glucose tolerance affect serum androgen levels in patients with polycystic ovary syndrome ? The Bulletin of Zeynep Kamil Sept. 2018; 49(3): 270-274 

 

Verbal Notices

* Bakir VL, Ozgur Dundar, Serkan Bodur, The effect of oophorectomy procedure on the morbidity of laparoscopy and laparotomy methods in the treatment of hysterectomy cases with benign uterine causes TJOD, 2017 , p; 122.

* Kanat-Pektas M, Bodur S, Dundar O, Bakır VL. Comparison of laparoscopy and laparotomy in terms of morbidity, complication blood transfusion and changes in hemoglobin level in the treatment of hysterectomy cases with benign uterine causes TJOD, 2017 , p; 76.

* Dane C, Doğu S, Abay M, Bakır VL, Akgüneş A, Güleç S, Ermin S, Doğan G Krukenberg Tumor Detected in Adnexal Mass in Pregnancy TJOD, 2017 , p; 133.

* Bakir VL. The comparison of ogtt and homa-ir tests in determining glucose tolerance in the polycstic overian syndrome TJOD, 2017 , p; 83.

* Bakir VL. The effect of vitamin-D level on clinical and metabolic findings in patients with Polycystic Ovary syndrome TAJEV, 2017 , p; 186.

* Koleli I, Bakir VL. Conservative management of a case of placenta percreta with parametrial invasion: a case report. 2019 SBU Gynocology andObstetrics, p; 54.

* Bakir VL. Is there any effect of obesity on menstrual period in patients with polycystic ovary syndrome? 9. National Obesity Congress. 2018, p; 62.

 

Poster Presentations

* Corbacioglu A, Bakir VL, Akbayir O, Cilesiz Goksedef BP, Akca A. "The clinical significance of classical and new emerging determinants of adenomyosis" X. Turkish German Gynecology Congress, 2012. p; 100.

* Polat I, Bakir VL, Hasbajrami A, Yildirim G, Ülker V, "Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width", X. Turkish German Gynecology Congress, 2012. p; 87.

* Corbacioglu A, Bakir VL, Akbayir O, Cilesiz Goksedef BP, Akca A."A successful minimally invasive treatment of cesarean scar pregnancy: A Case Report" TJOD, 2012, p; 93.

* Kara N, Yildirim Y, Tekirdag AI, Yildirim GY, Bakir VL, Gulac B, Yilmaz G, Fendal A. "Abdominal Wall Endometriosis: A case report" TJOD, 2013 , p; 101.

* Dundar O, Pektas MK, Bodur S, Bakır VL, Cetin A. "Concomitant ovarian and endometrial cancer: A case report" TAJEV , 2013 , p; 122.

* Ekmez M, Dane C, Akgüneş A, Ekmez F, Göksedef P, Aydın DS, Bakir VL, İnce S, Yücel E "Coexistence of bilateral dysgerminoma and pregnancy" TJOD, 2013 , p; 120.

* Akbayır O, Corbacıoglu Esmer A, Numanoglu C, Cılesız Goksedef BP, Akca A, Bakır VL, Kuru O. "Gastroschisis with Anencephaly: Case Report" TAJEV, 2014, p;62.

* Sariibrahim B, Cogendez E, Kayatas S, Asoglu MR, Koleli I, Bakir VL. "A Trisomy 21 Case with signs of non-immune fetal hydrops" TJOD, 2014 , p; 28.

* Kara N, Yildirim Y, Tekirdag AI, Yildirim GY, Bakir VL, Gulac B, Yilmaz G, Fendal A. "The perinatal effects of nuchal cord entanglement at birth" TJOD, 2014 , p; 77.

* Akbayır O, Corbacıoglu Esmer A, Numanoglu C, Cılesız Goksedef BP, Akca A, Bakır VL, Kuru O. "Management of an abnormal cervical histopathology diagnosed during pregnancy" TAJEV, 2014 , p;50.

* Akbayır O, Corbacıoglu Esmer A, Numanoglu C, Cılesız Goksedef BP, Akca A, Bakır VL, Kuru O. "Fetal hepatic calcification: A case report" TAJEV, 2015 , p;30.

* Kara N, Yildirim Y, Tekirdag AI, Yildirim GY, Bakir VL, Gulac B, Yilmaz G, Fendal A. "Fluctuations of dry eye symptoms during the menstrual cycle" TAJEV, 2015, p;154.

* Sakar MN, Atay AE, Demir S, Bakir VL, Demir B, Balsak D, Akay E, Ulusoy AI, Verit FF. "Incresed levels of CA 19-9 together with mature cystic teratoma" TAJEV, 2015 , p;40.

* Sakinci M, Kuru O, Olgan S, Gunduz S, Bakir VL, Kaya O, Bakirci IT. "The incidence of adenomyosis on hysterectomy specimens" TJOD, 2015 , p; 172.

* Kara N, Yildirim Y, Tekirdag AI, Yildirim GY, Bakir VL, Gulac B, Yilmaz G, Fendal A. "Value of endometrial thickness measurement in detection of endometrial pathologies" TJOD, 2015 , p; 163

* Ekmez M, Dane C, Akgüneş A, Ekmez F, Göksedef P, Aydın DS, Bakir VL, İnce S, Yücel E "The association between body mass index and endometrial pathologies" TJOD, 2016 , p; 124.

* Sakinci M, Kuru O, Olgan S, Gunduz S, Bakir VL, Kaya O, Bakirci IT"Acardiac twin together with a healthy new born: A case report" TAJEV, 2016 , p; 145

* Sakar MN, Atay AE, Demir S, Bakir VL, Demir B, Balsak D, Akay E, Ulusoy AI, Verit FF. "The distribution of endometrial pathologies according to stratified Body Mass Index of women with a diagnosis of premenopausal abnormal uterine bleeding" TAJEV, 2016 , p; 132.

* Dundar O, Pektas MK, Bodur S, Bakır VL, Cetin A. "The effect of smoking on endometrial pathologies" TAJEV, 2016 , p; 155.

* Bakir VL, Bakir B, Sanli S, Yildiz SO, Iyibozkurt AC, Kartal MG, Yavuz E "Pelvic pain due to a foreign body" TJOD, 2017 , p; 141.

* Ekmez M, Dane C, Akgüneş A, Ekmez F, Göksedef P, Aydın DS, Bakir VL, İnce S, Yücel E "The association between pelvic inflammatory disease risk and vaginal douche in women with intrauterine device" TJOD, 2017 , p; 78.

* Bakir VL, The clinical significance of classical and new emerging determinants of adenomyosis" TJOD, 2018 , p; 105

* Dundar O, Pektas MK, Bodur S, Bakır VL, Cetin A. "Recurrent pregnancy loss is associated with increased red cell distribution width and platelet distribution width" TJOD, 2018 , p;153.

* Bakir VL, "A successful minimally invasive treatment of cesarean scar pregnancy: A Case Report" TJOD, 2018 , p;98.

* Ekmez M, Dane C, Akgüneş A, Ekmez F, Göksedef P, Aydın DS, Bakir VL, İnce S, Yücel E "Abdominal Wall Endometriosis: A case report" TAJEV, 2018 , p; 140.

* Bakir VL, "Coexistence of bilateral dysgerminoma and pregnancy" TAJEV, 2018 , p; 141.

* Sakar MN, Atay AE, Demir S, Bakir VL, Demir B, Balsak D, Akay E, Ulusoy AI, Verit FF. "Gastroschisis with Anencephaly: Case Report" TAJEV, 2018 , p;145.

* Attar E, Balcı BK, Avcı B, Güler M, Kabakçı Z, Eltiok A, Bakir VL, Öncül A. The Effect of Endometriosis on Heart Rate Variability in Women With and Without Chronic Pelvic Pain. IPPS, Chicago 2018

 

Ongoing Research

* Artificial ovarian tissue in preserving female fertility; Gelma Based scaffold application – Istinye University ; Stem Cell and Tissue Engineering Program

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